Mesolimbic dopamine signals the value of work
نویسندگان
چکیده
منابع مشابه
The Mysterious Motivational Functions of Mesolimbic Dopamine
Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse. Although it has become traditional to label dopamine neurons as "reward" neurons, this is an overgeneralization, and it is important to distinguish between aspects ...
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Dopamine and opioid neurotransmitter systems share many functions such as regulation of reward and pleasure. μ-Opioid receptors (MOR) modulate the mesolimbic dopamine system in ventral tegmental area and striatum, key areas implicated in reward. We hypothesized that dopamine and opioid receptor availabilities correlate in vivo and that this correlation is altered in obesity, a disease with alte...
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To explore the functional consequences of cannabinoid withdrawal in the rat mesolimbic dopamine system, we investigated the anatomical morphology of the mesencephalic, presumed dopaminergic, neurons and their main post-synaptic target in the Nucleus Accumbens. We found that TH-positive neurons shrink and Golgi-stained medium spiny neurons loose dendritic spines in withdrawal rats after chronic ...
متن کاملMesolimbic dopamine dynamically tracks, and is causally linked to, discrete aspects of value-based decision making.
BACKGROUND To make appropriate choices, organisms must weigh the costs and benefits of potential valuable outcomes, a process known to involve the nucleus accumbens (NAc) and its dopaminergic input. However, it is currently unknown if dopamine dynamically tracks alterations in expected reward value online as behavioral preferences change and if so, if it is causally linked to specific component...
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Monoaminergic neurotransmitter dopamine plays a critical role in various vital functions including hormonal regulation, reward, emotions and food intake. Multiple aspects of food intake that include food selection, satiety and energy expenditure could be modulated by changes in central dopaminergic transmission (1,2). Several lines of research indicate that abnormal dopaminergic neurotransmissi...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2015
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.4173